![\"Artm\u0131\u015f](\"http:\/\/izmirkarsiyakakadindogummerkezi.com\/wp-content\/uploads\/2014\/08\/artmisnt.gif\")
Artm\u0131\u015f NT olan fetuslerde g\u00f6r\u00fclebilen durumlar<\/p><\/div>\n
Artm\u0131\u015f Nukal Translusensili Fetuslerin Akibeti<\/h1>\n
NT kal\u0131nl\u0131\u011f\u0131 ile kromozmal defekt, fetal kay\u0131p ve major fetal anomali prevelans\u0131 aras\u0131ndaki ili\u015fki tablo 1\u2019de g\u00f6sterilmi\u015ftir (Souka ve ark 2004).<\/p>\n
Kromozomal Defektler<\/h2>\n
Kromozomal defekt prevelans\u0131 NT kal\u0131nl\u0131\u011f\u0131na parallel olarak belirgin \u015fekilde artar (Tablo 1; Snijders ve ark 1988). Kromozomal olarak anormal gurubun;<\/p>\n
- \n
- % 50\u2019sini trizomi 21,<\/li>\n
- %25\u2019ini trizomi 18 veya 13,<\/li>\n
- %10\u2019unu Turner sendromu,<\/li>\n
- %5\u2019ini triploidi<\/li>\n
- %10\u2019u di\u011fer kromozomal defektler<\/li>\n<\/ul>\n
olu\u015fturur.<\/p>\n
Fetal \u00d6l\u00fcm<\/h2>\n
Kromozomal olarak normal olan fetuslarda fetal \u00f6l\u00fcm NT\u2019nin kal\u0131nla\u015fmas\u0131 ile belirgin \u015fekilde artar. Baz\u0131 olgularda NT art\u0131\u015f\u0131ndan ciddi hidropsa ilerleme g\u00f6r\u00fcl\u00fcr ve \u00e7o\u011fu 20. hafta civar\u0131nda intrauterin kaybedilirler.<\/p>\n
Fetal Anomaliler<\/h2>\n
Medikal ve\/veya cerrahi tedavi gerektiren ya da mental gerili\u011fe yol a\u00e7an anomali, major fetal anomali olarak tan\u0131mlan\u0131r. Fetal NT\u2019nin artt\u0131\u011f\u0131 olgularda, major fetal anomali prevelas\u0131n\u0131n da artt\u0131\u011f\u0131 pek \u00e7ok \u00e7al\u0131\u015fman\u0131n ortak sonucudur.<\/p>\n
Kromozom analiz sonucu normal olan, NT kal\u0131nl\u0131\u011f\u0131 ise artm\u0131\u015f bulunan, toplam 6.153 olguyu i\u00e7eren, 28 \u00e7al\u0131\u015fmada, major anomali prevelans\u0131 %7.3 olarak bulundu (Souka ve ark 2004). Ancak, incelen \u00e7al\u0131\u015fmalarda anormal NT olarak kabul edilen minimum NT kal\u0131nl\u0131\u011f\u0131 2\u20135 mm aras\u0131nda oldu\u011fu i\u00e7in, major anomali prevelanslar\u0131nda da %3 ile %50 aras\u0131nda de\u011fi\u015fen b\u00fcy\u00fck farkl\u0131l\u0131klar vard\u0131.<\/p>\n
Kromozom analiz sonucu normal olan fetuslardaki major fetal anomali prevelans\u0131 NT kal\u0131nl\u0131\u011f\u0131 ile artar.<\/p>\n
Geli\u015fme Gerili\u011fi<\/h2>\n
Kromozomal ve anotomik olarak normal olup, NT\u2019si artm\u0131\u015f olan fetuslar\u0131 do\u011fum sonras\u0131 uzun s\u00fcre izleyen \u00e7al\u0131\u015fmalara g\u00f6re, geli\u015fme gerili\u011finin prevelans\u0131 %2 ila %4 aras\u0131ndad\u0131r (Souka ve ark 2004). Ancak, \u00e7al\u0131\u015fmalardan sadece bir tanesinde kontrol grubu ile k\u0131yaslama yap\u0131ld\u0131\u011f\u0131 i\u00e7in, bu bulgular\u0131n anlaml\u0131l\u0131\u011f\u0131n\u0131 tam olarak de\u011ferlendirmek zordur.<\/p>\n
Brady ve ark (1998), fetal d\u00f6nemde NT\u2019si 3.5 mm ve \u00fczerinde olan 89 \u00e7ocuk ile NT\u2019si 3.5 mm\u2019nin alt\u0131nda olan 302 \u00e7ocu\u011fu klinik olarak takip ettiler. Bu \u00e7al\u0131\u015fmada, her iki gruptan birer \u00e7ocu\u011fun belirlenen geli\u015fim a\u015famalar\u0131ndan daha geri kald\u0131\u011f\u0131 saptand\u0131.<\/p>\n
Artm\u0131\u015f Nukal Translusensi \u0130le Birlikte Olan Anomaliler<\/h1>\n
NT\u2019si artm\u0131\u015f fetuslarda rastlanan geni\u015f anomali yelpazesi \u00f6zetlemi\u015ftir.<\/p>\n
![\"NT](\"http:\/\/izmirkarsiyakakadindogummerkezi.com\/wp-content\/uploads\/2014\/08\/artmisntsendrom.gif\")
NT art\u0131\u015f\u0131 \u015feklinde belirti veren sendromlar<\/p><\/div>\n
Anensefali, holoprozensefali, gastro\u015fizis, renal anomaliler ve spina bifida gibi baz\u0131 anomalilerin g\u00f6zlenen prevelanslar\u0131, toplumun genel prevelans\u0131ndan farkl\u0131 olmayabilir. Ancak, major kardiak anomali, diafragmatik herni, eksomfalos, \u201cbody stalk\u201d anomalisi, iskelet anomalisi ve konjenital adrenal hiperplazi, fetal akinezi deformasyon silsilesi, Noonan sendromu, Smith-Lemli-Optiz sendromu ve spinal musk\u00fcler atrofi gibi baz\u0131 genetik sendromlar\u0131n prevelans\u0131 ise genel toplumdakinden daha y\u00fcksektir. \u0130\u015fte bu nedenle artm\u0131\u015f NT ile bu tip anormaliler aras\u0131nda ger\u00e7ek bir ilgi olabilir.<\/p>\n","protected":false},"excerpt":{"rendered":"
NT kal\u0131nl\u0131\u011f\u0131n\u0131n artmas\u0131 trizomi 21 ve di\u011fer kromozomal defektlerin en yayg\u0131n fenotipik bulgusudur. Ayn\u0131 zamanda bebek \u00f6l\u00fcm\u00fc, pek \u00e7ok farkl\u0131 malformasyon, deformasyon ve disgenezi veya genetik sendrom ile de ilgili olabilir. Bu b\u00f6l\u00fcmde NT\u2019nin artm\u0131\u015f olmas\u0131 nedeni ile karyotipleme yap\u0131l\u0131p, kromozomal olarak normal oldu\u011fu saptanan fetuslar\u0131n akibetleri irdelenecektir. Bu bilgiler \u0131\u015f\u0131\u011f\u0131nda her NT gurubu i\u00e7in, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32],"tags":[],"yoast_head":"\n
Artm\u0131\u015f Nukal Translusensi ve Normal Karyotip - \u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Artm\u0131\u015f Nukal Translusensi ve Normal Karyotip - \u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi\" \/>\n<meta property=\"og:description\" content=\"NT kal\u0131nl\u0131\u011f\u0131n\u0131n artmas\u0131 trizomi 21 ve di\u011fer kromozomal defektlerin en yayg\u0131n fenotipik bulgusudur. Ayn\u0131 zamanda bebek \u00f6l\u00fcm\u00fc, pek \u00e7ok farkl\u0131 malformasyon, deformasyon ve disgenezi veya genetik sendrom ile de ilgili olabilir. Bu b\u00f6l\u00fcmde NT\u2019nin artm\u0131\u015f olmas\u0131 nedeni ile karyotipleme yap\u0131l\u0131p, kromozomal olarak normal oldu\u011fu saptanan fetuslar\u0131n akibetleri irdelenecektir. Bu bilgiler \u0131\u015f\u0131\u011f\u0131nda her NT gurubu i\u00e7in, […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi\" \/>\n<meta property=\"article:publisher\" content=\"http:\/\/facebook.com\/op.dr.hakankilavuz\" \/>\n<meta property=\"article:published_time\" content=\"2014-08-09T06:46:55+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/izmirkarsiyakakadindogummerkezi.com\/wp-content\/uploads\/2014\/08\/artmisnt.gif\" \/>\n<meta name=\"author\" content=\"hakan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@opdrkilavuz\" \/>\n<meta name=\"twitter:site\" content=\"@opdrkilavuz\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"hakan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/\",\"url\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/\",\"name\":\"Artm\u0131\u015f Nukal Translusensi ve Normal Karyotip - \u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi\",\"isPartOf\":{\"@id\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/#website\"},\"datePublished\":\"2014-08-09T06:46:55+00:00\",\"dateModified\":\"2014-08-09T06:46:55+00:00\",\"author\":{\"@id\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/#\/schema\/person\/8a752617726b9b02bd10a28c1c4509a4\"},\"breadcrumb\":{\"@id\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Ana sayfa\",\"item\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Artm\u0131\u015f Nukal Translusensi ve Normal Karyotip\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/#website\",\"url\":\"https:\/\/izmirkarsiyakakadindogummerkezi.com\/\",\"name\":\"\u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi\",\"description\":\"Op. 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Ayn\u0131 zamanda bebek \u00f6l\u00fcm\u00fc, pek \u00e7ok farkl\u0131 malformasyon, deformasyon ve disgenezi veya genetik sendrom ile de ilgili olabilir. Bu b\u00f6l\u00fcmde NT\u2019nin artm\u0131\u015f olmas\u0131 nedeni ile karyotipleme yap\u0131l\u0131p, kromozomal olarak normal oldu\u011fu saptanan fetuslar\u0131n akibetleri irdelenecektir. Bu bilgiler \u0131\u015f\u0131\u011f\u0131nda her NT gurubu i\u00e7in, […]","og_url":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/","og_site_name":"\u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi","article_publisher":"http:\/\/facebook.com\/op.dr.hakankilavuz","article_published_time":"2014-08-09T06:46:55+00:00","og_image":[{"url":"http:\/\/izmirkarsiyakakadindogummerkezi.com\/wp-content\/uploads\/2014\/08\/artmisnt.gif"}],"author":"hakan","twitter_card":"summary_large_image","twitter_creator":"@opdrkilavuz","twitter_site":"@opdrkilavuz","twitter_misc":{"Yazan:":"hakan","Tahmini okuma s\u00fcresi":"3 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/","url":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/","name":"Artm\u0131\u015f Nukal Translusensi ve Normal Karyotip - \u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi","isPartOf":{"@id":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/#website"},"datePublished":"2014-08-09T06:46:55+00:00","dateModified":"2014-08-09T06:46:55+00:00","author":{"@id":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/#\/schema\/person\/8a752617726b9b02bd10a28c1c4509a4"},"breadcrumb":{"@id":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/artmis-nukal-translusensi-ve-normal-karyotip\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Ana sayfa","item":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/"},{"@type":"ListItem","position":2,"name":"Artm\u0131\u015f Nukal Translusensi ve Normal Karyotip"}]},{"@type":"WebSite","@id":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/#website","url":"https:\/\/izmirkarsiyakakadindogummerkezi.com\/","name":"\u0130zmir Kar\u015f\u0131yaka Kad\u0131n Do\u011fum Merkezi","description":"Op. 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